Abstract
The folic acid antagonist, methotrexate, has many applications in the treatment of neoplastic disease. While methotrexate produces several well-recognized toxic effects, cutaneous reactions are rare. A patient who developed classical erythema multiforme while receiving low-dose methotrexate as treatment of nonmetastatic gestational trophoblastic neoplasia is presented. Erythema multiforme has been associated with a variety of pharmacologic agents. It typically presents as a pruritic papular dermatitis of the extensor surfaces of the extremities and may require multiple skin biopsies to establish the diagnosis. Spontaneous reversal usually occurs with discontinuation of therapy. Patients developing erythema multiforme related to antineoplastic agents should be switched to an alternate regimen.
Original language | English (US) |
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Pages (from-to) | 376-378 |
Number of pages | 3 |
Journal | Gynecologic oncology |
Volume | 33 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1989 |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology