Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer

Yan Lu; Shulin/SL Li; Shiguo/SG Zhu; Yabin/YB Gong; Jun/J Shi; Ling/ L. Xu

doi:10.1186/s12575-017-0051-8

Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer

Yan Lu, Shulin/SL Li, Shiguo/SG Zhu, Yabin/YB Gong, Jun/J Shi, Ling/ L. Xu

Pediatrics

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer.

Original language	English (US)
Article number	72
Journal	Biological Procedures Online
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12575-017-0051-8
State	Published - Mar 17 2017

Keywords

Circulating RNA
Liquid biopsy
Lung cancer
Methylation
ctDNA

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1186/s12575-017-0051-8

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abstract = "DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer.",

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AU - Lu, Yan

AU - Li, Shulin/SL

AU - Zhu, Shiguo/SG

AU - Gong, Yabin/YB

AU - Shi, Jun/J

AU - Xu, Ling/ L.

PY - 2017/3/17

Y1 - 2017/3/17

N2 - DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer.

AB - DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer.

KW - Circulating RNA

KW - Liquid biopsy

KW - Lung cancer

KW - Methylation

KW - ctDNA

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Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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