Mice without telomerase: What can they teach us about human cancer?

Steven E. Artandi; Ronald A. DePinho

doi:10.1038/78595

Mice without telomerase: What can they teach us about human cancer?

Steven E. Artandi, Ronald A. DePinho

Research output: Contribution to journal › Review article › peer-review

119 Scopus citations

Abstract

Unicellular organisms, human cells and mice have provided insights into how the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.

Original language	English (US)
Pages (from-to)	852-855
Number of pages	4
Journal	Nature medicine
Volume	6
Issue number	8
DOIs	https://doi.org/10.1038/78595
State	Published - Aug 2000
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Mice without telomerase: What can they teach us about human cancer?",

abstract = "Unicellular organisms, human cells and mice have provided insights into how the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.",

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AB - Unicellular organisms, human cells and mice have provided insights into how the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.

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Mice without telomerase: What can they teach us about human cancer?

Abstract

ASJC Scopus subject areas

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