TY - JOUR
T1 - Microbial Regulation of Vitamin D Linked to Colorectal Cancer
T2 - A Sex Bias
AU - Riquelme, Erick
AU - Howell, Rian M.
AU - McAllister, Florencia
N1 - Publisher Copyright:
2023 American Association for Cancer Research.
PY - 2023
Y1 - 2023
N2 - In a recent issue of Cancer Cell, Li and colleagues revealed that Carnobacterium maltaromaticum (C. maltaromaticum) was significantly depleted in the stool samples of patients with colorectal cancer in a female-specific manner. C. maltaromaticum actively participated in the generation of vitamin D intermediary metabolites, which together with Faecalibacterium prausnitzii and Lachnispiraceae bacterium produce an active metabolite of vitamin D that protects against colorectal cancer development. C. maltaromaticum supplementation induced in a female-specific manner an increase in vitamin D levels that would activate its receptor in the colonic epithelium, protecting against the development of colorectal cancer.
AB - In a recent issue of Cancer Cell, Li and colleagues revealed that Carnobacterium maltaromaticum (C. maltaromaticum) was significantly depleted in the stool samples of patients with colorectal cancer in a female-specific manner. C. maltaromaticum actively participated in the generation of vitamin D intermediary metabolites, which together with Faecalibacterium prausnitzii and Lachnispiraceae bacterium produce an active metabolite of vitamin D that protects against colorectal cancer development. C. maltaromaticum supplementation induced in a female-specific manner an increase in vitamin D levels that would activate its receptor in the colonic epithelium, protecting against the development of colorectal cancer.
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U2 - 10.1158/0008-5472.CAN-23-3128
DO - 10.1158/0008-5472.CAN-23-3128
M3 - Article
C2 - 37964614
AN - SCOPUS:85177075707
SN - 0008-5472
VL - 83
SP - 3670
EP - 3672
JO - Cancer Research
JF - Cancer Research
IS - 22
ER -