Microbiome and Cancer Metastasis

Michael G. White; Jennifer A. Wargo; Jennifer L. McQuade

doi:10.1007/978-3-030-93084-4_73

Microbiome and Cancer Metastasis

Michael G. White, Jennifer A. Wargo, Jennifer L. McQuade

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The commensal microbiome is a unique set of bacteria, viruses, and fungi that exist on and in a person’s body. As these organisms are increasingly understood as a necessary and symbiotic part of human health, they have also been associated with the development and progression of a variety of cancers. Additionally, these organisms have been noted to aid malignancies in their ability to evade host immune surveillance functions as well as inactivate cytotoxic chemotherapies. As the role of the tumor microenvironment and immune system is increasingly recognized as vital to the treatment of malignant disease, the gut, tumoral, and circulating microbiome must be included in this equation as well.

Original language	English (US)
Title of host publication	Cancer Metastasis Through the Lymphovascular System
Publisher	Springer International Publishing
Pages	767-773
Number of pages	7
ISBN (Electronic)	9783030930844
ISBN (Print)	9783030930837
DOIs	https://doi.org/10.1007/978-3-030-93084-4_73
State	Published - Jan 1 2022

Keywords

Carcinogenesis
Checkpoint inhibition
Immunotherapy
Microbiome
Preclinical models
Therapeutics

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

Access to Document

10.1007/978-3-030-93084-4_73

Cite this

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AU - White, Michael G.

AU - Wargo, Jennifer A.

AU - McQuade, Jennifer L.

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AB - The commensal microbiome is a unique set of bacteria, viruses, and fungi that exist on and in a person’s body. As these organisms are increasingly understood as a necessary and symbiotic part of human health, they have also been associated with the development and progression of a variety of cancers. Additionally, these organisms have been noted to aid malignancies in their ability to evade host immune surveillance functions as well as inactivate cytotoxic chemotherapies. As the role of the tumor microenvironment and immune system is increasingly recognized as vital to the treatment of malignant disease, the gut, tumoral, and circulating microbiome must be included in this equation as well.

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KW - Immunotherapy

KW - Microbiome

KW - Preclinical models

KW - Therapeutics

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Microbiome and Cancer Metastasis

Abstract

Keywords

ASJC Scopus subject areas

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