TY - JOUR
T1 - Microcystic adnexal carcinoma with sebaceous differentiation
T2 - Three cases
AU - Fernandez-Flores, Angel
AU - Llamas-Velasco, Mar
AU - Saus, Carles
AU - Patel, Anisha
AU - Rutten, Arno
N1 - Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful. In this study, we present 3 cases of MAC with focal sebaceous differentiation confirmed by immunoexpression of adipophilin in the sebaceous foci.
AB - Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful. In this study, we present 3 cases of MAC with focal sebaceous differentiation confirmed by immunoexpression of adipophilin in the sebaceous foci.
KW - adipophylin
KW - microcystic adnexal carcinoma
KW - sebaceous differentiation
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U2 - 10.1111/cup.13109
DO - 10.1111/cup.13109
M3 - Article
C2 - 29352496
AN - SCOPUS:85042037123
SN - 0303-6987
VL - 45
SP - 290
EP - 295
JO - Journal of cutaneous pathology
JF - Journal of cutaneous pathology
IS - 4
ER -