TY - JOUR
T1 - Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch
AU - Carstens, Julienne L.
AU - Lovisa, Sara
AU - Kalluri, Raghu
PY - 2014/4/1
Y1 - 2014/4/1
N2 - The metastatic spread of tumor epithelial cells accounts for over 90% of cancer-specific mortality; however, the molecular mechanisms that govern tumor spread and distant recolonization remain unclear. In this issue of JCI, Rokavec and colleagues shine light on this murky aspect of tumor biology by focusing through the lens of microenvironmental contributions, namely inflammation, as driving signals that set off a delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs. This study provides in vivo evidence and identifies molecular players behind the elusive switch that drives the epithelial-to-mesenchymal transition and the mesenchymal-to- epithelial transition.
AB - The metastatic spread of tumor epithelial cells accounts for over 90% of cancer-specific mortality; however, the molecular mechanisms that govern tumor spread and distant recolonization remain unclear. In this issue of JCI, Rokavec and colleagues shine light on this murky aspect of tumor biology by focusing through the lens of microenvironmental contributions, namely inflammation, as driving signals that set off a delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs. This study provides in vivo evidence and identifies molecular players behind the elusive switch that drives the epithelial-to-mesenchymal transition and the mesenchymal-to- epithelial transition.
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U2 - 10.1172/JCI75239
DO - 10.1172/JCI75239
M3 - Comment/debate
C2 - 24642461
AN - SCOPUS:84897502349
SN - 0021-9738
VL - 124
SP - 1458
EP - 1460
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -