MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney

Jianyin Long; Shawn S. Badal; Yin Wang; Benny H.J. Chang; Antony Rodriguez; Farhad R. Danesh

doi:10.1074/jbc.M113.498634

MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney

Jianyin Long, Shawn S. Badal, Yin Wang, Benny H.J. Chang, Antony Rodriguez, Farhad R. Danesh

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: BMPs have emerged as key regulators of kidney fibrosis. Results: Deletion of miR-22 attenuated renal fibrosis via direct targeting of BMP-7/6. BMP-7/6 in turn transcriptionally regulates miR-22 expression. Conclusion: miR-22 and BMP-7/6 form a negative feedback circuit. Significance: The present study is the first to report the effect of miR-22 on BMP signaling and kidney fibrosis.

Original language	English (US)
Pages (from-to)	36202-36214
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	51
DOIs	https://doi.org/10.1074/jbc.M113.498634
State	Published - Dec 20 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney",

abstract = "Background: BMPs have emerged as key regulators of kidney fibrosis. Results: Deletion of miR-22 attenuated renal fibrosis via direct targeting of BMP-7/6. BMP-7/6 in turn transcriptionally regulates miR-22 expression. Conclusion: miR-22 and BMP-7/6 form a negative feedback circuit. Significance: The present study is the first to report the effect of miR-22 on BMP signaling and kidney fibrosis.",

author = "Jianyin Long and Badal, {Shawn S.} and Yin Wang and Chang, {Benny H.J.} and Antony Rodriguez and Danesh, {Farhad R.}",

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T1 - MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney

AU - Long, Jianyin

AU - Badal, Shawn S.

AU - Wang, Yin

AU - Chang, Benny H.J.

AU - Rodriguez, Antony

AU - Danesh, Farhad R.

PY - 2013/12/20

Y1 - 2013/12/20

N2 - Background: BMPs have emerged as key regulators of kidney fibrosis. Results: Deletion of miR-22 attenuated renal fibrosis via direct targeting of BMP-7/6. BMP-7/6 in turn transcriptionally regulates miR-22 expression. Conclusion: miR-22 and BMP-7/6 form a negative feedback circuit. Significance: The present study is the first to report the effect of miR-22 on BMP signaling and kidney fibrosis.

AB - Background: BMPs have emerged as key regulators of kidney fibrosis. Results: Deletion of miR-22 attenuated renal fibrosis via direct targeting of BMP-7/6. BMP-7/6 in turn transcriptionally regulates miR-22 expression. Conclusion: miR-22 and BMP-7/6 form a negative feedback circuit. Significance: The present study is the first to report the effect of miR-22 on BMP signaling and kidney fibrosis.

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JO - Journal of Biological Chemistry

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MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney

Abstract

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