MicroRNA in leukemias

Deepa Sampath

doi:10.1007/978-94-007-4655-8_7

MicroRNA in leukemias

Deepa Sampath

Hematopoietic Biology & Malignancy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

MicroRNAs are a class of master gene regulators that are extensively deregulated in all leukemias. Distinctive miRNA signatures are expressed in each cytogenetically defined subtype of leukemia which play multifaceted roles in the genesis, pathobiology, progression and clinical outcome of this group of diseases. This chapter aims to provide a comprehensive review of the expression, regulation and cellular targets of the microRNAs in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) in order to understand the regulatory role of microRNA in the leukemias as well as to identify novel therapeutic targets.

Original language	English (US)
Title of host publication	MicroRNA in Cancer
Publisher	Springer Netherlands
Pages	97-118
Number of pages	22
ISBN (Electronic)	9789400746558
ISBN (Print)	9400746547, 9789400746541
DOIs	https://doi.org/10.1007/978-94-007-4655-8_7
State	Published - Apr 1 2013

ASJC Scopus subject areas

General Medicine

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10.1007/978-94-007-4655-8_7

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title = "MicroRNA in leukemias",

abstract = "MicroRNAs are a class of master gene regulators that are extensively deregulated in all leukemias. Distinctive miRNA signatures are expressed in each cytogenetically defined subtype of leukemia which play multifaceted roles in the genesis, pathobiology, progression and clinical outcome of this group of diseases. This chapter aims to provide a comprehensive review of the expression, regulation and cellular targets of the microRNAs in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) in order to understand the regulatory role of microRNA in the leukemias as well as to identify novel therapeutic targets.",

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AB - MicroRNAs are a class of master gene regulators that are extensively deregulated in all leukemias. Distinctive miRNA signatures are expressed in each cytogenetically defined subtype of leukemia which play multifaceted roles in the genesis, pathobiology, progression and clinical outcome of this group of diseases. This chapter aims to provide a comprehensive review of the expression, regulation and cellular targets of the microRNAs in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) in order to understand the regulatory role of microRNA in the leukemias as well as to identify novel therapeutic targets.

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MicroRNA in leukemias

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