MicroRNA machinery genes as novel biomarkers for cancer

Jing Tao Huang; Jin Wang; Vibhuti Srivastava; Subrata Sen; Song Mei Liu

doi:10.3389/fonc.2014.00113

MicroRNA machinery genes as novel biomarkers for cancer

Jing Tao Huang, Jin Wang, Vibhuti Srivastava, Subrata Sen, Song Mei Liu

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO₅, TRBP, and AGO₂, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.

Original language	English (US)
Article number	113
Journal	Frontiers in Oncology
Volume	4 MAY
DOIs	https://doi.org/10.3389/fonc.2014.00113
State	Published - 2014

Keywords

Alterations
Biomarker
Cancer
Machinery genes
MiRNA

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2014.00113

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title = "MicroRNA machinery genes as novel biomarkers for cancer",

abstract = "MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.",

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AU - Huang, Jing Tao

AU - Wang, Jin

AU - Srivastava, Vibhuti

AU - Sen, Subrata

AU - Liu, Song Mei

PY - 2014

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N2 - MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.

AB - MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.

KW - Alterations

KW - Biomarker

KW - Cancer

KW - Machinery genes

KW - MiRNA

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JO - Frontiers in Oncology

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MicroRNA machinery genes as novel biomarkers for cancer

Abstract

Keywords

ASJC Scopus subject areas

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