MicroRNAs as novel immunotherapeutics

Amy B. Heimberger; Mark Gilbert; Ganesh Rao; Jun Wei

doi:10.4161/onci.25124

MicroRNAs as novel immunotherapeutics

Amy B. Heimberger, Mark Gilbert, Ganesh Rao, Jun Wei

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

Original language	English (US)
Article number	e25124
Journal	OncoImmunology
Volume	2
Issue number	8
DOIs	https://doi.org/10.4161/onci.25124
State	Published - 2013

Keywords

Cancer stem cells
Glioblastoma multiforme
Immunosuppression
MicroRNAs
Regulatory T cells
Signal transducer and activator of transcription 3

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.25124

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title = "MicroRNAs as novel immunotherapeutics",

abstract = "A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.",

keywords = "Cancer stem cells, Glioblastoma multiforme, Immunosuppression, MicroRNAs, Regulatory T cells, Signal transducer and activator of transcription 3",

author = "Heimberger, {Amy B.} and Mark Gilbert and Ganesh Rao and Jun Wei",

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AU - Heimberger, Amy B.

AU - Gilbert, Mark

AU - Rao, Ganesh

AU - Wei, Jun

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AB - A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.

KW - Cancer stem cells

KW - Glioblastoma multiforme

KW - Immunosuppression

KW - MicroRNAs

KW - Regulatory T cells

KW - Signal transducer and activator of transcription 3

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MicroRNAs as novel immunotherapeutics

Abstract

Keywords

ASJC Scopus subject areas

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