TY - JOUR
T1 - MicroRNAs as therapeutic targets in nasopharyngeal carcinoma
AU - Wang, Sumei
AU - Claret, François Xavier
AU - Wu, Wanyin
N1 - Funding Information:
This work was supported by the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine (YN2016QJ03), the Guangdong Medical Science and Technology Research Foundation (A2018251), the doctoral research project of Guangdong Natural Science Foundation of China (2017A030310326), the China Postdoctoral Science Foundation Sixty-third Batches of Projects (2018M630941), the Guangzhou science and technology plan project (201804010149), the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine (A1260619111001), and the Science and Technology Planning Project of Guangdong Province (2017B030314166). We thank Butt, Bryan F from the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for editorial support.
Funding Information:
This work was supported by the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine (YN2016QJ03), the Guangdong Medical Science and Technology Research Foundation (A2018251), the doctoral research project of Guangdong Natural Science Foundation of China (2017A030310326), the China Postdoctoral Science Foundation Sixty-third Batches of Projects (2018M630941), the Guangzhou science and technology plan project (201804010149), the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine (A1260619111001), and the Science and Technology Planning Project of Guangdong Province (2017B030314166).
Publisher Copyright:
© 2019 Wang, Claret and Wu.
PY - 2019
Y1 - 2019
N2 - Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin that is prone to local invasion and early distant metastasis. Although concurrent chemotherapy and radiotherapy improves the 5-year survival outcomes, persistent or recurrent disease still occurs. Therefore, novel therapeutic targets are needed for NPC patients. MicroRNAs (miRNAs) play important roles in normal cell homeostasis, and dysregulations of miRNA expression have been implicated in human cancers. In NPC, studies have revealed that miRNAs are dysregulated and involved in tumorigenesis, metastasis, invasion, resistance to chemo-and radiotherapy, and other disease-and treatment-related processes. The advantage of miRNA-based treatment approaches is that miRNAs can concurrently target multiple effectors of pathways involved in tumor cell differentiation and proliferation. Thus, miRNA-based cancer treatments, alone or combined with standard chemotherapy and/or radiotherapy, hold promise to improve treatment response and cure rates. In this review, we will summarize the dysregulation of miRNAs in NPC initiation, progression, and treatment as well as NPC-related signaling pathways, and we will discuss the potential applications of miRNAs as biomarkers and therapeutic targets in NPC patients. We conclude that miRNAs might be potential promising therapeutic targets in nasopharyngeal carcinoma.
AB - Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin that is prone to local invasion and early distant metastasis. Although concurrent chemotherapy and radiotherapy improves the 5-year survival outcomes, persistent or recurrent disease still occurs. Therefore, novel therapeutic targets are needed for NPC patients. MicroRNAs (miRNAs) play important roles in normal cell homeostasis, and dysregulations of miRNA expression have been implicated in human cancers. In NPC, studies have revealed that miRNAs are dysregulated and involved in tumorigenesis, metastasis, invasion, resistance to chemo-and radiotherapy, and other disease-and treatment-related processes. The advantage of miRNA-based treatment approaches is that miRNAs can concurrently target multiple effectors of pathways involved in tumor cell differentiation and proliferation. Thus, miRNA-based cancer treatments, alone or combined with standard chemotherapy and/or radiotherapy, hold promise to improve treatment response and cure rates. In this review, we will summarize the dysregulation of miRNAs in NPC initiation, progression, and treatment as well as NPC-related signaling pathways, and we will discuss the potential applications of miRNAs as biomarkers and therapeutic targets in NPC patients. We conclude that miRNAs might be potential promising therapeutic targets in nasopharyngeal carcinoma.
KW - Application
KW - Biomarker
KW - MicroRNA
KW - Nasopharyngeal Carcinoma (NPC)
KW - Therapeutic target
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U2 - 10.3389/fonc.2019.00756
DO - 10.3389/fonc.2019.00756
M3 - Review article
C2 - 31456943
AN - SCOPUS:85071694466
SN - 2234-943X
VL - 9
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - AUG
M1 - 756
ER -