MicroRNAs: The jack of all trades

Sumaiyah K. Rehman; Gustavo Baldassarre; George A. Calin; Milena S. Nicoloso

doi:10.3816/CLK.2009.n.003

MicroRNAs: The jack of all trades

Sumaiyah K. Rehman, Gustavo Baldassarre, George A. Calin, Milena S. Nicoloso

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNA-targeted therapies, which should affect all the aspects of tumorigenesis.

Original language	English (US)
Pages (from-to)	20-32
Number of pages	13
Journal	Clinical Leukemia
Volume	3
Issue number	1
DOIs	https://doi.org/10.3816/CLK.2009.n.003
State	Published - Feb 2009

Keywords

Angiogenesis
Growth signaling
Tumorigenesis
miRNA

ASJC Scopus subject areas

Oncology
Hematology

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10.3816/CLK.2009.n.003

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title = "MicroRNAs: The jack of all trades",

abstract = "Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNA-targeted therapies, which should affect all the aspects of tumorigenesis.",

keywords = "Angiogenesis, Growth signaling, Tumorigenesis, miRNA",

author = "Rehman, {Sumaiyah K.} and Gustavo Baldassarre and Calin, {George A.} and Nicoloso, {Milena S.}",

note = "Funding Information: Dr. Calin is supported by an M. D. Anderson Trust grant and by a Regent scholarship and by the CLL Global Research Foundation. We apologize to our colleagues whose work was not cited because of space limitations.",

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doi = "10.3816/CLK.2009.n.003",

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T2 - The jack of all trades

AU - Rehman, Sumaiyah K.

AU - Baldassarre, Gustavo

AU - Calin, George A.

AU - Nicoloso, Milena S.

N1 - Funding Information: Dr. Calin is supported by an M. D. Anderson Trust grant and by a Regent scholarship and by the CLL Global Research Foundation. We apologize to our colleagues whose work was not cited because of space limitations.

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N2 - Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNA-targeted therapies, which should affect all the aspects of tumorigenesis.

AB - Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNA-targeted therapies, which should affect all the aspects of tumorigenesis.

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KW - Growth signaling

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MicroRNAs: The jack of all trades

Abstract

Keywords

ASJC Scopus subject areas

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