MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives

R. I. Aqeilan; G. A. Calin; C. M. Croce

doi:10.1038/cdd.2009.69

MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives

R. I. Aqeilan, G. A. Calin, C. M. Croce

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

562 Scopus citations

Abstract

MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	Cell death and differentiation
Volume	17
Issue number	2
DOIs	https://doi.org/10.1038/cdd.2009.69
State	Published - Feb 2010

Keywords

Apoptosis
BCL2
CLL
MiR15/16 cluster
MicroRNA

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cdd.2009.69

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title = "MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives",

abstract = "MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.",

keywords = "Apoptosis, BCL2, CLL, MiR15/16 cluster, MicroRNA",

author = "Aqeilan, {R. I.} and Calin, {G. A.} and Croce, {C. M.}",

note = "Funding Information: Acknowledgements. RIA is supported by a Ma{\textquoteright}of fellowship and NIH R01DK079217 grant. GAC is supported as a Fellow by The University of Texas M. D. Anderson Research Trust, as a Fellow of The University of Texas System Regents Research Scholar, and by the Ladjevardian Regents Research Scholar Fund. Work in CMC{\textquoteright}s laboratory is funded by the National Institutes of Health. The authors thank Virginia M Mohlere for the editing work on this manuscript.",

year = "2010",

month = feb,

doi = "10.1038/cdd.2009.69",

language = "English (US)",

volume = "17",

pages = "215--220",

journal = "Cell death and differentiation",

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T2 - Discovery, function and future perspectives

AU - Aqeilan, R. I.

AU - Calin, G. A.

AU - Croce, C. M.

N1 - Funding Information: Acknowledgements. RIA is supported by a Ma’of fellowship and NIH R01DK079217 grant. GAC is supported as a Fellow by The University of Texas M. D. Anderson Research Trust, as a Fellow of The University of Texas System Regents Research Scholar, and by the Ladjevardian Regents Research Scholar Fund. Work in CMC’s laboratory is funded by the National Institutes of Health. The authors thank Virginia M Mohlere for the editing work on this manuscript.

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N2 - MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.

AB - MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.

KW - Apoptosis

KW - BCL2

KW - CLL

KW - MiR15/16 cluster

KW - MicroRNA

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MiR-15a and miR-16-1 in cancer: Discovery, function and future perspectives

Abstract

Keywords

ASJC Scopus subject areas

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