Abstract
Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506 could augment the response to cisplatin and olaparib through targeting RAD51 and suppressing homologous recombination in a panel of ovarian cancer cell lines. Systemic delivery of miR-506 in an orthotopic ovarian cancer mouse model significantly augmented the cisplatin response, thus recapitulating the clinical observation. Therefore, miR-506 plays a functionally important role in homologous recombination and has important therapeutic value for sensitizing cancer cells to chemotherapy, especially in chemo-resistant patients with attenuated expression of miR-506.
Original language | English (US) |
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Article number | 44 |
Journal | Chinese Journal of Cancer |
Volume | 34 |
Issue number | 11 |
DOIs |
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State | Published - Sep 14 2015 |
Keywords
- Drug sensitivity
- Homologous recombination
- MicroRNA-506
- RAD51
- Synthetic lethality
ASJC Scopus subject areas
- Oncology