TY - JOUR
T1 - MiRNA response to DNA damage
AU - Wan, Guohui
AU - Mathur, Rohit
AU - Hu, Xiaoxiao
AU - Zhang, Xinna
AU - Lu, Xiongbin
N1 - Funding Information:
X.L. is supported by a National Institutes of Health grant (CA136549), a research grant from the American Cancer Society (119135-RSG-10-185-01-TBE) and the University of Texas Systems STARS PLUS Award. We apologize to our colleagues whose work we could not cite owing to length constraints.
PY - 2011/9
Y1 - 2011/9
N2 - Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors, transducers and effectors in cell cycle arrest, apoptosis and DNA repair. Emerging evidence has suggested that miRNAs play a crucial role in regulation of DNA damage response. In this review, we discuss the recent findings on how miRNAs interact with the canonical DNA damage response and how miRNA expression is regulated after DNA damage.
AB - Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors, transducers and effectors in cell cycle arrest, apoptosis and DNA repair. Emerging evidence has suggested that miRNAs play a crucial role in regulation of DNA damage response. In this review, we discuss the recent findings on how miRNAs interact with the canonical DNA damage response and how miRNA expression is regulated after DNA damage.
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U2 - 10.1016/j.tibs.2011.06.002
DO - 10.1016/j.tibs.2011.06.002
M3 - Review article
C2 - 21741842
AN - SCOPUS:80052391165
SN - 0968-0004
VL - 36
SP - 478
EP - 484
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 9
ER -