Mismatched Lesions on 18F-FDG PET and 18F-Fluciclovine PET Images in a Patient with Metastatic Prostate Small Cell Carcinoma

Joshua Gu, Yang Lu, Guofan Xu

Research output: Contribution to journalArticlepeer-review

Abstract

A 65-year-old man with fluciclovine-avid metastatic prostate small cell carcinoma with prostate-specific antigen (PSA) 19.4 ng/mL at diagnosis underwent system therapy and subsequent surgery and achieved hormonal response with PSA <0.1 ng/mL. An 18F-fluciclovine PET/CT scan 3 months after surgery was negative for disease. Although PSA remained <0.1 ng/mL, the rising carcinoembryonic antigen prompted an 18F-FDG PET/CT 6 weeks later. It showed multiple hypermetabolic lesions in the prostatectomy bed, liver, and right iliac bone, suggestive of malignant disease. The FDG-avid prostatectomy lesions were further confirmed on MRI. This case demonstrates that FDG PET/CT has a role in suspected metastatic prostate small cell carcinoma with negative fluciclovine PET examination.

Original languageEnglish (US)
Pages (from-to)255-257
Number of pages3
JournalClinical nuclear medicine
Volume47
Issue number3
DOIs
StatePublished - Mar 1 2022
Externally publishedYes

Keywords

  • FDG
  • PET/CT
  • fluciclovine
  • metastasis
  • prostate small cell carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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