Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest

Young Jae Lee; Chang Won Park; Yoonsoo Hahn; Jeongmin Park; Jieun Lee; Ji Hye Yun; Byunghwa Hyun; Jae Hoon Chung

doi:10.1016/S0014-5793(00)01461-7

Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest

Young Jae Lee, Chang Won Park, Yoonsoo Hahn, Jeongmin Park, Jieun Lee, Ji Hye Yun, Byunghwa Hyun, Jae Hoon Chung

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues. Copg2 consists of 24 exons within the >40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2. In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. Copyright (C) 2000 Federation of European Biochemical Societies.

Original language	English (US)
Pages (from-to)	230-234
Number of pages	5
Journal	FEBS Letters
Volume	472
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(00)01461-7
State	Published - Apr 28 2000
Externally published	Yes

Keywords

Antisense RNA
Coatomer protein complex
Imprinting
Peg1/Mest

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(00)01461-7

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title = "Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest",

abstract = "Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues. Copg2 consists of 24 exons within the >40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2. In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. Copyright (C) 2000 Federation of European Biochemical Societies.",

keywords = "Antisense RNA, Coatomer protein complex, Imprinting, Peg1/Mest",

author = "Lee, {Young Jae} and Park, {Chang Won} and Yoonsoo Hahn and Jeongmin Park and Jieun Lee and Yun, {Ji Hye} and Byunghwa Hyun and Chung, {Jae Hoon}",

note = "Funding Information: This work was supported by a grant from Korea Science and Engineering Foundation (grant no. 1999-1-210-001-3). ",

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doi = "10.1016/S0014-5793(00)01461-7",

language = "English (US)",

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AU - Lee, Young Jae

AU - Park, Chang Won

AU - Hahn, Yoonsoo

AU - Park, Jeongmin

AU - Lee, Jieun

AU - Yun, Ji Hye

AU - Hyun, Byunghwa

AU - Chung, Jae Hoon

N1 - Funding Information: This work was supported by a grant from Korea Science and Engineering Foundation (grant no. 1999-1-210-001-3).

PY - 2000/4/28

Y1 - 2000/4/28

N2 - Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues. Copg2 consists of 24 exons within the >40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2. In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2. The gene is maternally imprinted in adult mouse brain, partially imprinted in other tissues. Copg2 consists of 24 exons within the >40 kb genomic region, being expressed ubiquitously in mouse tissues with a partial imprinting pattern in embryos, neonates, and adult brain in contrast to maternally imprinted human COPG2. In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - Antisense RNA

KW - Coatomer protein complex

KW - Imprinting

KW - Peg1/Mest

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Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest

Abstract

Keywords

ASJC Scopus subject areas

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