@inbook{f2aeeee73e7a4e54af92fd8256044f24,
title = "Mitochondrial alterations during carcinogenesis. A review of metabolic transformation and targets for anticancer treatments",
abstract = "Mitochondria play important roles in multiple cellular processes including energy metabolism, cell death, and aging. Regulated energy production and utilization are critical in maintaining energy homeostasis in normal cells and functional organs. However, mitochondria go through a series of morphological and functional alterations during carcinogenesis. The metabolic profile in transformed cells is altered to accommodate their fast proliferation, confer resistance to cell death, or facilitate metastasis. These transformations also provide targets for anticancer treatment at different levels. In this review, we discuss the major modifications in cell metabolism during carcinogenesis, including energy metabolism, apoptotic and autophagic cell death, adaptation of tumor microenvironment, and metastasis. We also summarize some of the main metabolic targets for treatments.",
keywords = "HIF1, Hypoxia, Microenvironment, Mitochondria, MtDNA, ROS, Respiration, Warburg",
author = "Xiao Wang and Susana Peralta and Moraes, {Carlos T.}",
note = "Funding Information: Our work is supported in part by the National Institutes of Health Grants 1R01AG036871, 1R01NS079965, 5R01CA085700, and 5R01EY010804 and the Muscular Dystrophy Association. The authors declare no competing financial interests.",
year = "2013",
doi = "10.1016/B978-0-12-407190-2.00004-6",
language = "English (US)",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "127--160",
booktitle = "Advances in Cancer Research",
}