TY - JOUR
T1 - Mitochondrial tumour suppressors
T2 - A genetic and biochemical update
AU - Gottlieb, Eyal
AU - Tomlinson, Ian P.M.
PY - 2005/11
Y1 - 2005/11
N2 - Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal cell carcinomas. Here we review recent advances in the field of mitochondrial tumour suppressors, the biochemical pathway that links mitochondrial dysfunction with tumorigenesis, and potential therapeutic approaches to these malignancies.
AB - Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly recognized to include malignant tumours, such as malignant phaeochromocytomas and renal cell carcinomas. Here we review recent advances in the field of mitochondrial tumour suppressors, the biochemical pathway that links mitochondrial dysfunction with tumorigenesis, and potential therapeutic approaches to these malignancies.
UR - http://www.scopus.com/inward/record.url?scp=28544446058&partnerID=8YFLogxK
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U2 - 10.1038/nrc1737
DO - 10.1038/nrc1737
M3 - Review article
C2 - 16327764
AN - SCOPUS:28544446058
SN - 1474-175X
VL - 5
SP - 857
EP - 866
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 11
ER -