Abstract
The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.
Original language | English (US) |
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Pages (from-to) | 332-334 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 626 |
Issue number | 1-2 |
DOIs | |
State | Published - Oct 29 1993 |
Keywords
- Antinociception
- MK-801
- NMDA
- Opiate tolerance
- Spinal cord
- Tail flick test
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology