Models of malignant glioma

Ken Aldape; Howard Colman; C. David James

doi:10.1016/j.ddmod.2006.06.002

Models of malignant glioma

Ken Aldape, Howard Colman, C. David James

Pathology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Malignant gliomas are biologically and clinically aggressive neoplasms with a high mortality rate. Recent therapeutic advances have been modest and incremental at best. An increased understanding of the factors, which promote progressive biologic and clinical behavior, is needed to improve upon current therapeutic modalities. Model systems of glioma, which accurately reflect the biology of the human disease, show promise as a means to accomplish this goal.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmod.2006.06.002
State	Published - 2006

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2006.06.002

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title = "Models of malignant glioma",

abstract = "Malignant gliomas are biologically and clinically aggressive neoplasms with a high mortality rate. Recent therapeutic advances have been modest and incremental at best. An increased understanding of the factors, which promote progressive biologic and clinical behavior, is needed to improve upon current therapeutic modalities. Model systems of glioma, which accurately reflect the biology of the human disease, show promise as a means to accomplish this goal.",

author = "Ken Aldape and Howard Colman and James, {C. David}",

year = "2006",

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T1 - Models of malignant glioma

AU - Aldape, Ken

AU - Colman, Howard

AU - James, C. David

PY - 2006

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N2 - Malignant gliomas are biologically and clinically aggressive neoplasms with a high mortality rate. Recent therapeutic advances have been modest and incremental at best. An increased understanding of the factors, which promote progressive biologic and clinical behavior, is needed to improve upon current therapeutic modalities. Model systems of glioma, which accurately reflect the biology of the human disease, show promise as a means to accomplish this goal.

AB - Malignant gliomas are biologically and clinically aggressive neoplasms with a high mortality rate. Recent therapeutic advances have been modest and incremental at best. An increased understanding of the factors, which promote progressive biologic and clinical behavior, is needed to improve upon current therapeutic modalities. Model systems of glioma, which accurately reflect the biology of the human disease, show promise as a means to accomplish this goal.

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UR - http://www.scopus.com/inward/citedby.url?scp=33747349033&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2006.06.002

DO - 10.1016/j.ddmod.2006.06.002

M3 - Review article

AN - SCOPUS:33747349033

SN - 1740-6757

VL - 3

SP - 191

EP - 196

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

IS - 2

ER -

Models of malignant glioma

Abstract

ASJC Scopus subject areas

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