TY - JOUR
T1 - Models of reactive oxygen species in cancer
AU - Lu, Weiqin
AU - Ogasawara, Marcia A.
AU - Huang, Peng
N1 - Funding Information:
This work was supported partly by grants CA085563, CA100428 and CA109041 from the National Cancer Institute, National Institutes of Health.
PY - 2007
Y1 - 2007
N2 - Increased generation of reactive oxygen species (ROS) has been observed in cancer, degenerative diseases and other pathological conditions. ROS can stimulate cell proliferation, promote genetic instability and induce adaptive responses that enable cancer cells to maintain their malignant phenotypes. However, when cellular redox balance is severely disturbed, high levels of ROS might cause various damages leading to cell death. The studies of ROS effects on biological systems, their underlying mechanisms and therapeutic implications largely depend on proper experimental models. Here we review several in vitro and in vivo models for ROS research.
AB - Increased generation of reactive oxygen species (ROS) has been observed in cancer, degenerative diseases and other pathological conditions. ROS can stimulate cell proliferation, promote genetic instability and induce adaptive responses that enable cancer cells to maintain their malignant phenotypes. However, when cellular redox balance is severely disturbed, high levels of ROS might cause various damages leading to cell death. The studies of ROS effects on biological systems, their underlying mechanisms and therapeutic implications largely depend on proper experimental models. Here we review several in vitro and in vivo models for ROS research.
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U2 - 10.1016/j.ddmod.2007.10.005
DO - 10.1016/j.ddmod.2007.10.005
M3 - Review article
C2 - 18591999
AN - SCOPUS:40849131132
SN - 1740-6757
VL - 4
SP - 67
EP - 73
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 2
ER -