Modulation of Schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cells during chronic infection

Adel El Naggar; Daniel G. Colley

doi:10.1016/0008-8749(82)90292-1

Modulation of Schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cells during chronic infection

Adel El Naggar, Daniel G. Colley

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6 Scopus citations

Abstract

Chronic schistosomiasis mansoni is associated with a modulation of schistosome egg-associated cell-mediated granuloma formation. In this study the injection of a cell-free sonicate from either spleen or thymus cells from chronic Schistosoma mansoni-infected mice (> 15 weeks) passively modulated granuloma size in acutely infected (6-8 weeks) syngeneic mice. Cell-free sonicates from age-matched uninfected mice did not suppress granuloma formation. The chronic extracts also suppressed the soluble schistosome egg antigenic preparation-elicited delayed skin test reactivity in 7-8 week infected animals, but failed to suppress the unrelated antigen-elicited reactivity to bovine serum albumin (BSA) of BSA-sensitized animals.

Original language	English (US)
Pages (from-to)	151-156
Number of pages	6
Journal	Cellular Immunology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(82)90292-1
State	Published - Sep 1 1982
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(82)90292-1

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@article{48e68c1fe070474e89d2e21192b1dffc,

title = "Modulation of Schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cells during chronic infection",

abstract = "Chronic schistosomiasis mansoni is associated with a modulation of schistosome egg-associated cell-mediated granuloma formation. In this study the injection of a cell-free sonicate from either spleen or thymus cells from chronic Schistosoma mansoni-infected mice (> 15 weeks) passively modulated granuloma size in acutely infected (6-8 weeks) syngeneic mice. Cell-free sonicates from age-matched uninfected mice did not suppress granuloma formation. The chronic extracts also suppressed the soluble schistosome egg antigenic preparation-elicited delayed skin test reactivity in 7-8 week infected animals, but failed to suppress the unrelated antigen-elicited reactivity to bovine serum albumin (BSA) of BSA-sensitized animals.",

author = "{El Naggar}, Adel and Colley, {Daniel G.}",

note = "Funding Information: {\textquoteright} This work was supported by Grant AI-I 1289 from the National Institutes of Health and the Veterans Administration. * Present address: Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44 106. 3 Abbreviations: BSA, bovine serum albumin; DTH, delayed-type hypersensitivity; SEA, soluble schistosomal egg antigenic preparation; TsF, T lymphocyte-derived suppressor factor.",

year = "1982",

month = sep,

day = "1",

doi = "10.1016/0008-8749(82)90292-1",

language = "English (US)",

volume = "72",

pages = "151--156",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "1",

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T1 - Modulation of Schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cells during chronic infection

AU - El Naggar, Adel

AU - Colley, Daniel G.

N1 - Funding Information: ’ This work was supported by Grant AI-I 1289 from the National Institutes of Health and the Veterans Administration. * Present address: Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44 106. 3 Abbreviations: BSA, bovine serum albumin; DTH, delayed-type hypersensitivity; SEA, soluble schistosomal egg antigenic preparation; TsF, T lymphocyte-derived suppressor factor.

PY - 1982/9/1

Y1 - 1982/9/1

N2 - Chronic schistosomiasis mansoni is associated with a modulation of schistosome egg-associated cell-mediated granuloma formation. In this study the injection of a cell-free sonicate from either spleen or thymus cells from chronic Schistosoma mansoni-infected mice (> 15 weeks) passively modulated granuloma size in acutely infected (6-8 weeks) syngeneic mice. Cell-free sonicates from age-matched uninfected mice did not suppress granuloma formation. The chronic extracts also suppressed the soluble schistosome egg antigenic preparation-elicited delayed skin test reactivity in 7-8 week infected animals, but failed to suppress the unrelated antigen-elicited reactivity to bovine serum albumin (BSA) of BSA-sensitized animals.

AB - Chronic schistosomiasis mansoni is associated with a modulation of schistosome egg-associated cell-mediated granuloma formation. In this study the injection of a cell-free sonicate from either spleen or thymus cells from chronic Schistosoma mansoni-infected mice (> 15 weeks) passively modulated granuloma size in acutely infected (6-8 weeks) syngeneic mice. Cell-free sonicates from age-matched uninfected mice did not suppress granuloma formation. The chronic extracts also suppressed the soluble schistosome egg antigenic preparation-elicited delayed skin test reactivity in 7-8 week infected animals, but failed to suppress the unrelated antigen-elicited reactivity to bovine serum albumin (BSA) of BSA-sensitized animals.

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JF - Cellular Immunology

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Modulation of Schistosoma mansoni egg-induced granuloma formation. II. Soluble suppressor activity from lymphoid cells during chronic infection

Abstract

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