@article{9eb2a6174ac94b00a9114c41ec97782c,
title = "Modulation of the Gut Microbiome to Enhance Immunotherapy Response in Metastatic Melanoma Patients: A Clinical Review",
abstract = "For patients with metastatic melanoma, immunotherapy agents represent a promising treatment option, and researchers are actively seeking to identify factors that may predict a favorable response in patients. Recent studies have elucidated possible associations between the gut microbiome and the effects of immunotherapy, where variations in the gut microbiome may influence treatment response and frequency of adverse effects. In this clinical review, we describe the current literature related to the gut microbiome in the setting of immunotherapy, and we provide an overview of interventions under investigation that may modulate the gut microbiome. These interventions include fecal microbiota transplantation, probiotics, and dietary modifications.",
keywords = "Advanced melanoma, Anti-CTLA-4, Anti-PD-1, Fecal microbiota transplantation, Gut microbiome, Immunotherapy, Metastatic melanoma",
author = "Maleka Najmi and Tiffaney Tran and Witt, {Russell G.} and Nelson, {Kelly C.}",
note = "Funding Information: Tiffaney Tran is supported by a Melanoma Research Foundation grant. Russell Witt is supported by a National Institutes of Health T32 grant (CA 009599) and an MD Anderson Cancer Center support grant (P30 CA016672). Kelly C. Nelson is supported by philanthropic contributions of the Lyda Hill Foundation to the MD Anderson Cancer Center Moon Shots Program{\texttrademark}. No sponsorship was received for this study or the publication of this article. The Rapid Service Fee was funded by the authors. Funding Information: Tiffaney Tran is supported by a Melanoma Research Foundation grant. Russell Witt is supported by a National Institutes of Health T32 grant (CA 009599) and an MD Anderson Cancer Center support grant (P30 CA016672). Kelly C. Nelson is supported by philanthropic contributions of the Lyda Hill Foundation to the MD Anderson Cancer Center Moon Shots Program{\texttrademark}. No sponsorship was received for this study or the publication of this article. The Rapid Service Fee was funded by the authors. Kelly C. Nelson and Maleka Najmi contributed to the study conceptualization and design and performed the literature search. An initial evidence review was performed by Maleka Najmi. The first draft of the manuscript was written by Maleka Najmi, and all authors commented on previous versions of the manuscript. All authors reviewed and approved the final manuscript. Maleka Najmi, Tiffaney Tran, Russell Witt, and Kelly Nelson have no conflicts of interest to disclose. This review is based on published literature and does not contain any new studies with human participants or animals performed by any of the authors. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = nov,
doi = "10.1007/s13555-022-00810-1",
language = "English (US)",
volume = "12",
pages = "2489--2497",
journal = "Dermatology and Therapy",
issn = "2193-8210",
publisher = "Springer Verlag",
number = "11",
}