Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes

Cobi J. Heijnen; Jitske Zijlstra; Annemieke Kavelaars; Gerda Croiset; Rudy E. Ballieux

doi:10.1016/0889-1591(87)90031-6

Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes

Cobi J. Heijnen, Jitske Zijlstra, Annemieke Kavelaars, Gerda Croiset, Rudy E. Ballieux

Symptom Research CAO

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Abstract

The POMC-derived peptides β-endorphin and ACTH are capable of modulating an immune response in physiological concentrations. These neuropeptides can either enhance or inhibit the proliferative response of human peripheral blood lymphocytes after stimulation with the mitogen concanavalin A. The modulatory action of the peptides is not only dependent on the concentration but appears to be donor dependent. The response pattern observed is not determined by a selective affinity for certain amino acid sites on the molecules with "enhancing" or "inhibiting" activities, since fragments of β-endorphin and ACTH also produce a differential donor-dependent response pattern.

Original language	English (US)
Pages (from-to)	284-291
Number of pages	8
Journal	Brain Behavior and Immunity
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0889-1591(87)90031-6
State	Published - Dec 1987

ASJC Scopus subject areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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AU - Croiset, Gerda

AU - Ballieux, Rudy E.

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Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes

Abstract

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