Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation

Annemieke Kavelaars; Rudy E. Ballieux; Cobi Heijnen

doi:10.1016/0889-1591(88)90006-2

Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation

Annemieke Kavelaars, Rudy E. Ballieux, Cobi Heijnen

Symptom Research CAO

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Abstract

In this paper the effect of ACTH 1-24 is described on one of the "early events" occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10^-10 M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli.

Original language	English (US)
Pages (from-to)	57-66
Number of pages	10
Journal	Brain Behavior and Immunity
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0889-1591(88)90006-2
State	Published - Mar 1988

ASJC Scopus subject areas

Immunology
Endocrine and Autonomic Systems
Behavioral Neuroscience

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10.1016/0889-1591(88)90006-2

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Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation. / Kavelaars, Annemieke; Ballieux, Rudy E.; Heijnen, Cobi.
In: Brain Behavior and Immunity, Vol. 2, No. 1, 03.1988, p. 57-66.

Research output: Contribution to journal › Article › peer-review

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title = "Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation",

abstract = "In this paper the effect of ACTH 1-24 is described on one of the {"}early events{"} occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10-10 M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli.",

author = "Annemieke Kavelaars and Ballieux, {Rudy E.} and Cobi Heijnen",

note = "Funding Information: The authors are greatly indebted to Dr. J. C. Kreeftenberg (National Institute for Public Health and Environmental Hygiene, Bilthoven, the Netherlands) for providing the monoclonal antibody RIV9. They also thank Linda Gramberg for preparing the manuscript. The technical assistance of Jitske Zijlstra is gratefully acknowledged. This work was supported in part by the Dutch Asthma Foundation, Grant 84.21.",

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AU - Kavelaars, Annemieke

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AU - Heijnen, Cobi

N1 - Funding Information: The authors are greatly indebted to Dr. J. C. Kreeftenberg (National Institute for Public Health and Environmental Hygiene, Bilthoven, the Netherlands) for providing the monoclonal antibody RIV9. They also thank Linda Gramberg for preparing the manuscript. The technical assistance of Jitske Zijlstra is gratefully acknowledged. This work was supported in part by the Dutch Asthma Foundation, Grant 84.21.

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N2 - In this paper the effect of ACTH 1-24 is described on one of the "early events" occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10-10 M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli.

AB - In this paper the effect of ACTH 1-24 is described on one of the "early events" occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10-10 M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli.

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Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation

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