Abstract
Modulation of interactions between human breast carcinoma cells (MCF-7ras) and fibroblasts from normal breast tissue (MG3) and from a post-radiation fibrosis with recurrent breast carcinoma (FPR7) by a dextran derivative (CMDB7) was investigated. In a coculture system, MCF-7ras proliferation was increased (50%) by fibroblasts, and fibroblasts showed a 84% growth increase with MCF-7ras. This co-stimulation did nor depend on fibroblast origin. CMDB7 can inhibit the growth of MCF-7ras but not the growth of fibroblasts. The addition of CMDB7 blocks the MCF-7ras stimulation by fibroblasts but not the fibroblast stimulation by MCF-7ras. Fibroblast-Conditioned Medium stimulated over 2-3 fold MCF-7ras's DNA synthesis but CMDB7 did not influence this paracrine stimulation. IGFI, IGFII stimulated MCF-7ras's DNA synthesis whereas bFGF inhibited it. CMDB7 did not block IGFI and IGFII's stimulatory effects but inn eased bFGF's inhibitory effects These results indicate that CMDB7 can inhibit fibroblast-breast cancer cell interactions possibly by interfering with paracrine growth factor loops.
Original language | English (US) |
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Pages (from-to) | 253-258 |
Number of pages | 6 |
Journal | Anticancer research |
Volume | 17 |
Issue number | 1 A |
State | Published - 1997 |
Externally published | Yes |
Keywords
- Breast cancer cells
- Dextran derivatives
- Fibroblast
- Fibroblast growth
- Interaction
ASJC Scopus subject areas
- Oncology
- Cancer Research