@article{3552dd9776bc4eb9b051b68d6da55b9c,
title = "Molecular and clinical progress in follicular lymphoma lacking the t(14;18) translocation (Review)",
abstract = "Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18) (q32;q21). It is considered that BCL2 overexpression underscores the development of the majority of cases of FL and their transformation to more aggressive lymphoma [known as transformed FL (tFL)]. However, FL cases lacking the t(14;18) (q32;q21) translocation exhibit symptoms analogous to their t(14;18)-positive counterparts. An important goal of recent research on FL has been to clarify the distinctions between the two different forms of FL. Numerous studies have shed light onto the genetic and molecular features of t(14;18)-negative FL and the related clinical manifestations. In this review, we summarize the current knowledge of t(14;18)-negative FL occurring in the lymph nodes with an emphasis on the underlying molecular and clinical features. In addition, novel treatment directions are discussed.",
keywords = "BCL2, BCL6, Chromosome translocation, Follicular lymphoma, IGH, R-CHOP, T(14;18)-negative follicular lymphoma",
author = "Zunmin Zhu and Tao Li and Xuran Zhang and Zhengqiang Zhang and Dandan Zhu and Pei Lin and Shichun Tu and Weihong Ren",
note = "Funding Information: This study was supported in part by grants from Colleges and Universities Key Scientific Research Project Plan Basic Research Special of Henan Province (grant no. 19zx009), Science and Technology Project for Tackling Key Problems of Henan Province (grant no. 182102311172), Basic and Frontier Technology Research Program of Henan Province (grant no. 132300410448), and Science and Technology Innovation Talent Program of Henan Province (grant no. 154100510019). Funding Information: This study was supported in part by grants from Colleges and Universities Key Scientific Research Project Plan Basic Research Special of Henan Province (grant no. 19zx009), Science and Technology Project for Tackling Key Problems of Henan Province (grant no. 182102311172), Basic and Frontier Technology Research Program of Henan Province (grant no. 132300410448), and Science and Technology Innovation Talent Program of Henan Province (grant no. 154100510019) Publisher Copyright: {\textcopyright} 2020 Spandidos Publications. All rights reserved.",
year = "2020",
doi = "10.3892/ijo.2019.4917",
language = "English (US)",
volume = "56",
pages = "7--17",
journal = "International journal of oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "1",
}