Abstract
Viral-associated malignancies usually arise in the setting of altered immunity or with declines in immune function associated with aging. The main culprits are the lymphotropic herpesvirus, including Epstein-Barr virus (EBV) and human herpesvirus-8, which are the focus of this review. Chronic persistent infection and viral reactivation are the main risk factors for development of herpesvirus-associated malignancies and have provided the rationale for intensive monitoring of viral loads in some clinical contexts. Quantitative detection of EBV levels in the post-transplant period and following treatment of EBV-associated malignancies now have a proven role in outcome prediction. Both T-cell immunotherapy and humoral immunotherapies directed against latent viral antigens represent promising interventional approaches to treatment of viral-associated malignancies.
Original language | English (US) |
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Pages (from-to) | 831-841 |
Number of pages | 11 |
Journal | Expert Review of Molecular Diagnostics |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - 2006 |
Keywords
- Castleman's disease
- EBV
- HHV8
- Lymphoma
- Post-transplant lymphoproliferative disorders
- SV40
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Medicine
- Molecular Biology
- Genetics