Molecular biology of leukemias

L. Jeffrey Medeiros; Sergej N. Konoplev

doi:10.1007/978-1-59745-458-2_30

Molecular biology of leukemias

L. Jeffrey Medeiros, Sergej N. Konoplev

Hematopathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Normal hematopoiesis is a meticulously controlled process of cell division and differentiation arising from hematopoietic stem cells with self-renewal capacity. This process is regulated through several signaling pathways that appear to be, to some degree, redundant. In many neoplastic processes, alteration of one or several signaling pathways has been observed, implicating these pathways in pathogenesis.

Original language	English (US)
Title of host publication	The Molecular Basis of Human Cancer
Publisher	Springer New York
Pages	505-559
Number of pages	55
ISBN (Electronic)	9781597454582
ISBN (Print)	9781934115183
DOIs	https://doi.org/10.1007/978-1-59745-458-2_30
State	Published - Jan 1 2016

Keywords

8p11 myeloproliferative syndrome
ALL
AML
Acute lymphoblastic leukemia
Acute myeloid leukemia
Acute promyelocytic leukemia APL
BPDCN
Blastic plasmacytoid dendritic cell neoplasm
CML
Chronic lymphoid leukemias
Chronic myelogenous leukemia
Gene mutations
Leukemias

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-59745-458-2_30

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title = "Molecular biology of leukemias",

abstract = "Normal hematopoiesis is a meticulously controlled process of cell division and differentiation arising from hematopoietic stem cells with self-renewal capacity. This process is regulated through several signaling pathways that appear to be, to some degree, redundant. In many neoplastic processes, alteration of one or several signaling pathways has been observed, implicating these pathways in pathogenesis.",

keywords = "8p11 myeloproliferative syndrome, ALL, AML, Acute lymphoblastic leukemia, Acute myeloid leukemia, Acute promyelocytic leukemia APL, BPDCN, Blastic plasmacytoid dendritic cell neoplasm, CML, Chronic lymphoid leukemias, Chronic myelogenous leukemia, Gene mutations, Leukemias",

author = "{Jeffrey Medeiros}, L. and Konoplev, {Sergej N.}",

year = "2016",

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doi = "10.1007/978-1-59745-458-2_30",

language = "English (US)",

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AU - Jeffrey Medeiros, L.

AU - Konoplev, Sergej N.

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N2 - Normal hematopoiesis is a meticulously controlled process of cell division and differentiation arising from hematopoietic stem cells with self-renewal capacity. This process is regulated through several signaling pathways that appear to be, to some degree, redundant. In many neoplastic processes, alteration of one or several signaling pathways has been observed, implicating these pathways in pathogenesis.

AB - Normal hematopoiesis is a meticulously controlled process of cell division and differentiation arising from hematopoietic stem cells with self-renewal capacity. This process is regulated through several signaling pathways that appear to be, to some degree, redundant. In many neoplastic processes, alteration of one or several signaling pathways has been observed, implicating these pathways in pathogenesis.

KW - 8p11 myeloproliferative syndrome

KW - ALL

KW - AML

KW - Acute lymphoblastic leukemia

KW - Acute myeloid leukemia

KW - Acute promyelocytic leukemia APL

KW - BPDCN

KW - Blastic plasmacytoid dendritic cell neoplasm

KW - CML

KW - Chronic lymphoid leukemias

KW - Chronic myelogenous leukemia

KW - Gene mutations

KW - Leukemias

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DO - 10.1007/978-1-59745-458-2_30

M3 - Chapter

AN - SCOPUS:85018862933

SN - 9781934115183

SP - 505

EP - 559

BT - The Molecular Basis of Human Cancer

PB - Springer New York

ER -

Molecular biology of leukemias

Abstract

Keywords

ASJC Scopus subject areas

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