TY - JOUR
T1 - Molecular biomarkers for the evaluation of colorectal cancer
T2 - Guideline from The American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology
AU - Sepulveda, Antonia R.
AU - Hamilton, Stanley R.
AU - Allegra, Carmen J.
AU - Grody, Wayne
AU - Cushman-Vokoun, Allison M.
AU - Funkhouser, William K.
AU - Kopetz, Scott E.
AU - Lieu, Christopher
AU - Lindor, Noralane M.
AU - Minsky, Bruce D.
AU - Monzon, Federico A.
AU - Sargent, Daniel J.
AU - Singh, Veena M.
AU - Willis, Joseph
AU - Clark, Jennifer
AU - Colasacco, Carol
AU - Rumble, R. Bryan
AU - Temple-Smolkin, Robyn
AU - Ventura, Christina B.
AU - Nowak, Jan A.
N1 - Publisher Copyright:
© 2017 by American Society for Clinical Pathology.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Purpose: Molecular testing of colorectal cancers (CRCs) to improve patient care and outcomes of targeted and conventional therapies has been the center of many recent studies, including clinical trials. Evidencebased recommendations for the molecular testing of CRC tissues to guide epidermal growth factor receptor (EGFR) -targeted therapies and conventional chemotherapy regimens are warranted in clinical practice. The purpose of this guideline is to develop evidence-based recommendations to help establish standard molecular biomarker testing for CRC through a systematic review of the literature. Methods: The American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) convened an Expert Panel to develop an evidence-based guideline to help establish standard molecular biomarker testing, guide targeted therapies, and advance personalized care for patients with CRC. A comprehensive literature search that included over 4,000 articles was conducted to gather data to inform this guideline. Results: Twenty-one guideline statements (eight recommendations, 10 expert consensus opinions and three no recommendations) were established. Recommendations: Evidence supports mutational testing for genes in the EGFR signaling pathway, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize molecular testing for predictive and prognostic molecular biomarkers involve selection of assays, type of specimens to be tested, timing of ordering of tests and turnaround time for testing results.
AB - Purpose: Molecular testing of colorectal cancers (CRCs) to improve patient care and outcomes of targeted and conventional therapies has been the center of many recent studies, including clinical trials. Evidencebased recommendations for the molecular testing of CRC tissues to guide epidermal growth factor receptor (EGFR) -targeted therapies and conventional chemotherapy regimens are warranted in clinical practice. The purpose of this guideline is to develop evidence-based recommendations to help establish standard molecular biomarker testing for CRC through a systematic review of the literature. Methods: The American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP), and the American Society of Clinical Oncology (ASCO) convened an Expert Panel to develop an evidence-based guideline to help establish standard molecular biomarker testing, guide targeted therapies, and advance personalized care for patients with CRC. A comprehensive literature search that included over 4,000 articles was conducted to gather data to inform this guideline. Results: Twenty-one guideline statements (eight recommendations, 10 expert consensus opinions and three no recommendations) were established. Recommendations: Evidence supports mutational testing for genes in the EGFR signaling pathway, since they provide clinically actionable information as negative predictors of benefit to anti-EGFR monoclonal antibody therapies for targeted therapy of CRC. Mutations in several of the biomarkers have clear prognostic value. Laboratory approaches to operationalize molecular testing for predictive and prognostic molecular biomarkers involve selection of assays, type of specimens to be tested, timing of ordering of tests and turnaround time for testing results.
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U2 - 10.1200/JCO.2016.71.9807
DO - 10.1200/JCO.2016.71.9807
M3 - Article
C2 - 28165299
AN - SCOPUS:85012064093
SN - 0732-183X
VL - 35
SP - 1453
EP - 1496
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 13
ER -