TY - JOUR
T1 - Molecular characteristics and potential therapeutic targets in Merkel cell carcinoma
AU - Mauzo, Shakuntala H.
AU - Ferrarotto, Renata
AU - Bell, Diana
AU - Torres-Cabala, Carlos A.
AU - Tetzlaff, Michael T.
AU - Prieto, Victor G.
AU - Aung, Phyu P.
PY - 2016/5
Y1 - 2016/5
N2 - Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumour occurring preferentially in elderly and immunosuppressed individuals. Multiple studies have provided insight into the molecular alterations of MCC, leading to the design of several ongoing clinical trials testing chemotherapy, targeted therapy and immunotherapy in patients with recurrent or metastatic disease. The results of some of these studies are available, whereas others are eagerly awaited and will likely shed light on the understanding of MCC biology and potentially improve the clinical outcomes of patients with this rare disease.
AB - Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumour occurring preferentially in elderly and immunosuppressed individuals. Multiple studies have provided insight into the molecular alterations of MCC, leading to the design of several ongoing clinical trials testing chemotherapy, targeted therapy and immunotherapy in patients with recurrent or metastatic disease. The results of some of these studies are available, whereas others are eagerly awaited and will likely shed light on the understanding of MCC biology and potentially improve the clinical outcomes of patients with this rare disease.
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U2 - 10.1136/jclinpath-2015-203467
DO - 10.1136/jclinpath-2015-203467
M3 - Review article
C2 - 26818033
AN - SCOPUS:84962190463
SN - 0021-9746
VL - 69
SP - 382
EP - 390
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 5
ER -