TY - JOUR
T1 - Molecular cytopathology diagnosis of a lung neoplasm
T2 - Case report of an unusual non-small cell carcinoma with MET exon 14 skipping mutation
AU - Hosseini, S. Mohsen
AU - Khanafshar, Elham
AU - Seeley, Eric J.
AU - Ruiz-Cordero, Roberto
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/7
Y1 - 2021/7
N2 - Here we report the combined cytological and molecular diagnosis of a lung mass. The cytology and extensive immunohistochemistry on an endobronchial ultrasound-guided fine needle aspiration biopsy were inconclusive. By genomic profiling of the cell block material, we identified a MET exon 14 skipping mutation that indicated a lung origin and made the patient eligible for the tyrosine kinase inhibitor, crizotinib. This case is a prime example of complementing adequate aspiration and cell block processing techniques with molecular testing. Such an approach would augment the usability of fine needle aspiration biopsy, both as a diagnostic modality and as the first line to find therapeutic targets in the era of precision medicine.
AB - Here we report the combined cytological and molecular diagnosis of a lung mass. The cytology and extensive immunohistochemistry on an endobronchial ultrasound-guided fine needle aspiration biopsy were inconclusive. By genomic profiling of the cell block material, we identified a MET exon 14 skipping mutation that indicated a lung origin and made the patient eligible for the tyrosine kinase inhibitor, crizotinib. This case is a prime example of complementing adequate aspiration and cell block processing techniques with molecular testing. Such an approach would augment the usability of fine needle aspiration biopsy, both as a diagnostic modality and as the first line to find therapeutic targets in the era of precision medicine.
KW - MET exon 14 skipping
KW - fine-needle aspiration biopsy
KW - molecular cytopathology
KW - molecular diagnostics
KW - non-small-cell lung carcinoma
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U2 - 10.1002/dc.24694
DO - 10.1002/dc.24694
M3 - Article
C2 - 33433963
AN - SCOPUS:85099234724
SN - 8755-1039
VL - 49
SP - E258-E261
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
IS - 7
ER -