Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q

Frederico O. Gleber-Netto; Boudewijn J.M. Braakhuis; Asterios Triantafyllou; Robert P. Takes; Natalie Kelner; Juan P. Rodrigo; Primož Strojan; Vincent Vander Poorten; Alexander D. Rapidis; Alessandra Rinaldo; Ruud H. Brakenhoff; Alfio Ferlito; Luiz P. Kowalski

doi:10.1016/j.oraloncology.2015.04.016

Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q

Frederico O. Gleber-Netto, Boudewijn J.M. Braakhuis, Asterios Triantafyllou, Robert P. Takes, Natalie Kelner, Juan P. Rodrigo, Primož Strojan, Vincent Vander Poorten, Alexander D. Rapidis, Alessandra Rinaldo, Ruud H. Brakenhoff, Alfio Ferlito, Luiz P. Kowalski

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management.

Original language	English (US)
Pages (from-to)	738-744
Number of pages	7
Journal	Oral Oncology
Volume	51
Issue number	8
DOIs	https://doi.org/10.1016/j.oraloncology.2015.04.016
State	Published - 2015

Keywords

Molecular diagnosis
Oral cancer
Recurrence
Relapse
Second primary neoplasm
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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10.1016/j.oraloncology.2015.04.016

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Gleber-Netto, F. O., Braakhuis, B. J. M., Triantafyllou, A., Takes, R. P., Kelner, N., Rodrigo, J. P., Strojan, P., Poorten, V. V., Rapidis, A. D., Rinaldo, A., Brakenhoff, R. H., Ferlito, A., & Kowalski, L. P. (2015). Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q. Oral Oncology, 51(8), 738-744. https://doi.org/10.1016/j.oraloncology.2015.04.016

Gleber-Netto, FO, Braakhuis, BJM, Triantafyllou, A, Takes, RP, Kelner, N, Rodrigo, JP, Strojan, P, Poorten, VV, Rapidis, AD, Rinaldo, A, Brakenhoff, RH, Ferlito, A & Kowalski, LP 2015, 'Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q', Oral Oncology, vol. 51, no. 8, pp. 738-744. https://doi.org/10.1016/j.oraloncology.2015.04.016

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title = "Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q",

abstract = "Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management.",

keywords = "Molecular diagnosis, Oral cancer, Recurrence, Relapse, Second primary neoplasm, Squamous cell carcinoma",

author = "Gleber-Netto, {Frederico O.} and Braakhuis, {Boudewijn J.M.} and Asterios Triantafyllou and Takes, {Robert P.} and Natalie Kelner and Rodrigo, {Juan P.} and Primo{\v z} Strojan and Poorten, {Vincent Vander} and Rapidis, {Alexander D.} and Alessandra Rinaldo and Brakenhoff, {Ruud H.} and Alfio Ferlito and Kowalski, {Luiz P.}",

year = "2015",

doi = "10.1016/j.oraloncology.2015.04.016",

language = "English (US)",

volume = "51",

pages = "738--744",

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T1 - Molecular events in relapsed oral squamous cell carcinoma

T2 - Recurrence vs secondary primary tumor q

AU - Gleber-Netto, Frederico O.

AU - Braakhuis, Boudewijn J.M.

AU - Triantafyllou, Asterios

AU - Takes, Robert P.

AU - Kelner, Natalie

AU - Rodrigo, Juan P.

AU - Strojan, Primož

AU - Poorten, Vincent Vander

AU - Rapidis, Alexander D.

AU - Rinaldo, Alessandra

AU - Brakenhoff, Ruud H.

AU - Ferlito, Alfio

AU - Kowalski, Luiz P.

PY - 2015

Y1 - 2015

N2 - Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management.

AB - Relapses have a great impact on both the morbidity and mortality rates of oral squamous cell carcinoma (OSCC) patients. Current classification criteria are imprecise and need improvements. Recent advances in understanding of OSCC relapses on a molecular level provide new possibilities to better classify true recurrences and second primary tumors. This review discusses the limitations of the current OSCC relapse classification method and presents possible alternatives to improve this classification based on molecular techniques. Moreover, these molecular techniques add to the further understanding of these lesions and may provide tools for clinical management.

KW - Molecular diagnosis

KW - Oral cancer

KW - Recurrence

KW - Relapse

KW - Second primary neoplasm

KW - Squamous cell carcinoma

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DO - 10.1016/j.oraloncology.2015.04.016

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SN - 1368-8375

VL - 51

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JO - Oral Oncology

JF - Oral Oncology

IS - 8

ER -

Molecular events in relapsed oral squamous cell carcinoma: Recurrence vs secondary primary tumor q

Abstract

Keywords

ASJC Scopus subject areas

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