TY - JOUR
T1 - Molecular imaging strategies for drug discovery and development
AU - Gross, Shimon
AU - Piwnica-Worms, David
N1 - Funding Information:
The authors would like to thank colleagues in the Washington University Molecular Imaging Center for their insightful discussions contributing to this review. Supported by NIH P50 CA94056.
PY - 2006/8
Y1 - 2006/8
N2 - Recent advances in non-invasive molecular imaging provide exciting opportunities for discovery, validation and development of novel therapeutics. As the arsenal of detection devices and strategies, injectable probes, genetically encoded reporters and animal models rapidly expands, molecular imaging is becoming indispensable for drug discovery and development. Not only do such strategies reduce the time, cost and workload associated with conventional destructive end-point assays, but they also enable spatial and temporal monitoring of in vivo gene expression, signaling pathways, biochemical reactions and targets as they relate to the pharmacokinetics and pharmacodynamics of novel drugs.
AB - Recent advances in non-invasive molecular imaging provide exciting opportunities for discovery, validation and development of novel therapeutics. As the arsenal of detection devices and strategies, injectable probes, genetically encoded reporters and animal models rapidly expands, molecular imaging is becoming indispensable for drug discovery and development. Not only do such strategies reduce the time, cost and workload associated with conventional destructive end-point assays, but they also enable spatial and temporal monitoring of in vivo gene expression, signaling pathways, biochemical reactions and targets as they relate to the pharmacokinetics and pharmacodynamics of novel drugs.
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U2 - 10.1016/j.cbpa.2006.06.028
DO - 10.1016/j.cbpa.2006.06.028
M3 - Review article
C2 - 16822702
AN - SCOPUS:33746058605
SN - 1367-5931
VL - 10
SP - 334
EP - 342
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 4
ER -