TY - JOUR
T1 - Molecular markers in head and neck squamous cell carcinoma
T2 - Their biological function and prognostic significance
AU - Smith, B. D.
AU - Haffty, B. G.
AU - Sasaki, C. T.
PY - 2001
Y1 - 2001
N2 - Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.
AB - Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.
KW - Head and neck cancer
KW - Molecular markers
KW - Prognostic factors
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U2 - 10.1177/000348940111000304
DO - 10.1177/000348940111000304
M3 - Article
C2 - 11269765
AN - SCOPUS:0035104374
SN - 0003-4894
VL - 110
SP - 221
EP - 228
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - 3
ER -