Molecular mechanisms of head and neck cancer

Marxa L. Figueiredo; Yong Kim; Xiaofeng C. Zhou; Jeffrey N. Myers; David D.T. Wong

doi:10.1016/j.ddmec.2004.10.003

Molecular mechanisms of head and neck cancer

Marxa L. Figueiredo, Yong Kim, Xiaofeng C. Zhou, Jeffrey N. Myers, David D.T. Wong

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and the overall 50% five-year survival rate is among the lowest of the major cancers. Alterations in cellular molecules controlling DNA repair, proliferation, apoptosis, invasion and angiogenesis are known to contribute to the development of HNSCC. This review will focus on the molecular changes contributing to the pathogenesis of HNSCC and their clinical implications in designing new therapeutic strategies.

Original language	English (US)
Pages (from-to)	273-281
Number of pages	9
Journal	Drug Discovery Today: Disease Mechanisms
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmec.2004.10.003
State	Published - Nov 2004

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2004.10.003

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title = "Molecular mechanisms of head and neck cancer",

abstract = "Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and the overall 50% five-year survival rate is among the lowest of the major cancers. Alterations in cellular molecules controlling DNA repair, proliferation, apoptosis, invasion and angiogenesis are known to contribute to the development of HNSCC. This review will focus on the molecular changes contributing to the pathogenesis of HNSCC and their clinical implications in designing new therapeutic strategies.",

author = "Figueiredo, {Marxa L.} and Yong Kim and Zhou, {Xiaofeng C.} and Myers, {Jeffrey N.} and Wong, {David D.T.}",

year = "2004",

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language = "English (US)",

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journal = "Drug Discovery Today: Disease Mechanisms",

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T1 - Molecular mechanisms of head and neck cancer

AU - Figueiredo, Marxa L.

AU - Kim, Yong

AU - Zhou, Xiaofeng C.

AU - Myers, Jeffrey N.

AU - Wong, David D.T.

PY - 2004/11

Y1 - 2004/11

N2 - Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and the overall 50% five-year survival rate is among the lowest of the major cancers. Alterations in cellular molecules controlling DNA repair, proliferation, apoptosis, invasion and angiogenesis are known to contribute to the development of HNSCC. This review will focus on the molecular changes contributing to the pathogenesis of HNSCC and their clinical implications in designing new therapeutic strategies.

AB - Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide and the overall 50% five-year survival rate is among the lowest of the major cancers. Alterations in cellular molecules controlling DNA repair, proliferation, apoptosis, invasion and angiogenesis are known to contribute to the development of HNSCC. This review will focus on the molecular changes contributing to the pathogenesis of HNSCC and their clinical implications in designing new therapeutic strategies.

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U2 - 10.1016/j.ddmec.2004.10.003

DO - 10.1016/j.ddmec.2004.10.003

M3 - Review article

AN - SCOPUS:23744509484

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VL - 1

SP - 273

EP - 281

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 2

ER -

Molecular mechanisms of head and neck cancer

Abstract

ASJC Scopus subject areas

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