Abstract
CD4+ T cells are the master regulators of adaptive immune responses, and many autoimmune diseases arise due to a breakdown of self-tolerance in CD4+ T cells. Activation of CD4+ T cells is regulated by not only the binding of peptide-major histocompatibility complexes to T-cell receptor but also costimulatory signals from antigen-presenting cells. Recently, there has been progress in understanding the extracellular and intracellular mechanisms that are required for implementation and maintenance of T-cell tolerance. Understanding of the molecular mechanisms underlying T-cell tolerance will lead to development of pharmacological approaches either to promote the tolerance state in terms of autoimmunity or to break tolerance in cancer.
Original language | English (US) |
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Pages (from-to) | 133-144 |
Number of pages | 12 |
Journal | Immunological Reviews |
Volume | 241 |
Issue number | 1 |
DOIs | |
State | Published - May 2011 |
Keywords
- Costimulation
- E3 ubiquitin ligases
- Epigenetics
- Tolerance
- Transcription
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology