Abstract
Mutations in the p53 tumor suppressor gene are involved in the molecular pathogenesis of adenocarcinomas in Barrett’s esophagus in approximately 50% of patients. They occur at an early stage of tumor development presumably prior to the development of invasive cancer in premalignant Barrett’s epithelium. The majority of mutations are transition-type mutations, which is in striking contrast to esophageal squamous cell carcinomas and favors a different molecular pathogenesis for the two types of esophageal cancer. A prospective long-term study in a substantial number of patients with benign Barrett’s esophagus is mandatory to finally elucidate the role of p53 mutations as a marker for the malignant potential of Barrett’s epithelium.
Original language | English (US) |
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Pages (from-to) | 36-40 |
Number of pages | 5 |
Journal | Oncology research and treatment |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1997 |
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research