Molecular Pathology of Cutaneous Adnexal Tumors

Cutaneous adnexal neoplasms are relatively rare neoplasms that may occur sporadic or associated with inherited syndromes and visceral neoplasms. Early and correct recognition of these lesions is of outmost importance for patient’s follow-up, prognosis, and therapeutic options, especially since cutaneous lesions may sometimes be the first manifestation of the disease. In certain instances, the presence of usually multiple, specific cutaneous adnexal neoplasms is considered patognomonic for a syndrome. The cutaneous neoplasms are usually benign in nature, often share similar histopathologic features with their sporadic counterparts, and sometimes may provide histologic clues that suggest an associated syndrome.