Abstract
The substituted base, 6-(β-hydroxyethyl)guanine, has been identified in DNA which has been treated with the antitumor agent, N,N1-bis(2-chloroethyl)-N-nitrosourea (BCNU). This finding provides support for the suggestion that interstrand crosslinks may involve substitution at this position. The presence of 6-hydroxyethylguanine in DNA could also explain the carcinogenic potential of the haloethyl nitrosoureas since this DNA modification is considered mutagenic.
Original language | English (US) |
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Pages (from-to) | 351-357 |
Number of pages | 7 |
Journal | Biochemical and biophysical research communications |
Volume | 100 |
Issue number | 1 |
DOIs | |
State | Published - May 15 1981 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology