TY - JOUR
T1 - Molecular profiles of invasive mucinous and ductal carcinomas of the breast
T2 - A molecular case study
AU - Pusztai, Lajos
AU - Sotiriou, Christos
AU - Buchholz, Thomas A.
AU - Meric, Funda
AU - Symmans, W. Fraser
AU - Esteva, Francisco J.
AU - Sahin, Aysegul
AU - Liu, Edison T.
AU - Hortobagi, Gabriel N.
N1 - Funding Information:
Dr. Buchholz received a grant from the Physician Referral Service of the M.D. Anderson Cancer Center, and Dr. Esteva is a recipient of a Career Development Award from the National Cancer Institute (K23 CA82119).
PY - 2003/3
Y1 - 2003/3
N2 - Expression profiling using cDNA microarrays have redefined the molecular classification of some cancers. The comprehensive genetic analysis also permits the identification of novel pathways that might determine subtle differences in tumor phenotype. Herein, we analyzed the tissues from a patient with bilateral cancer of different histologies in each breast (pure invasive mucinous and pure invasive ductal), thus providing a unique opportunity to assess the expression profiles determined by histology in an isogenic human background. Our results show that the mucinous phenotype is associated with the expression of immunostimulatory and inhibitory genes, consistent with the cellular infiltration of lymphocytes and with the expression of enzymes involved in mucin production. Moreover, the panel of matrix metallo-proteinases are distinctly different between the mucinous and the invasive tumors, suggesting that therapeutic targets to this class of compounds may need to be tailored for the varying histologies. Taken together, these data suggest that expression profiling can be used diagnostically to distinguish individual histologic subclassifications and may guide the selection of target therapeutics.
AB - Expression profiling using cDNA microarrays have redefined the molecular classification of some cancers. The comprehensive genetic analysis also permits the identification of novel pathways that might determine subtle differences in tumor phenotype. Herein, we analyzed the tissues from a patient with bilateral cancer of different histologies in each breast (pure invasive mucinous and pure invasive ductal), thus providing a unique opportunity to assess the expression profiles determined by histology in an isogenic human background. Our results show that the mucinous phenotype is associated with the expression of immunostimulatory and inhibitory genes, consistent with the cellular infiltration of lymphocytes and with the expression of enzymes involved in mucin production. Moreover, the panel of matrix metallo-proteinases are distinctly different between the mucinous and the invasive tumors, suggesting that therapeutic targets to this class of compounds may need to be tailored for the varying histologies. Taken together, these data suggest that expression profiling can be used diagnostically to distinguish individual histologic subclassifications and may guide the selection of target therapeutics.
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U2 - 10.1016/S0165-4608(02)00737-9
DO - 10.1016/S0165-4608(02)00737-9
M3 - Article
C2 - 12606133
AN - SCOPUS:0037370628
SN - 0165-4608
VL - 141
SP - 148
EP - 153
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -