TY - JOUR
T1 - Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer
AU - Chrisikos, Taylor T.
AU - Zhou, Yifan
AU - Slone, Natalie
AU - Babcock, Rachel
AU - Watowich, Stephanie S.
AU - Li, Haiyan S.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/6
Y1 - 2019/6
N2 - Dendritic cells (DCs)are the principal antigen-presenting cells of the immune system and play key roles in controlling immune tolerance and activation. As such, DCs are chief mediators of tumor immunity. DCs can regulate tolerogenic immune responses that facilitate unchecked tumor growth. Importantly, however, DCs also mediate immune-stimulatory activity that restrains tumor progression. For instance, emerging evidence indicates the cDC1 subset has important functions in delivering tumor antigens to lymph nodes and inducing antigen-specific lymphocyte responses to tumors. Moreover, DCs control specific therapeutic responses in cancer including those resulting from immune checkpoint blockade. DC generation and function is influenced profoundly by cytokines, as well as their intracellular signaling proteins including STAT transcription factors. Regardless, our understanding of DC regulation in the cytokine-rich tumor microenvironment is still developing and must be better defined to advance cancer treatment. Here, we review literature focused on the molecular control of DCs, with a particular emphasis on cytokine- and STAT-mediated DC regulation. In addition, we highlight recent studies that delineate the importance of DCs in anti-tumor immunity and immune therapy, with the overall goal of improving knowledge of tumor-associated factors and intrinsic DC signaling cascades that influence DC function in cancer.
AB - Dendritic cells (DCs)are the principal antigen-presenting cells of the immune system and play key roles in controlling immune tolerance and activation. As such, DCs are chief mediators of tumor immunity. DCs can regulate tolerogenic immune responses that facilitate unchecked tumor growth. Importantly, however, DCs also mediate immune-stimulatory activity that restrains tumor progression. For instance, emerging evidence indicates the cDC1 subset has important functions in delivering tumor antigens to lymph nodes and inducing antigen-specific lymphocyte responses to tumors. Moreover, DCs control specific therapeutic responses in cancer including those resulting from immune checkpoint blockade. DC generation and function is influenced profoundly by cytokines, as well as their intracellular signaling proteins including STAT transcription factors. Regardless, our understanding of DC regulation in the cytokine-rich tumor microenvironment is still developing and must be better defined to advance cancer treatment. Here, we review literature focused on the molecular control of DCs, with a particular emphasis on cytokine- and STAT-mediated DC regulation. In addition, we highlight recent studies that delineate the importance of DCs in anti-tumor immunity and immune therapy, with the overall goal of improving knowledge of tumor-associated factors and intrinsic DC signaling cascades that influence DC function in cancer.
KW - Antigen presentation
KW - Cytokine
KW - Dendritic cell
KW - Molecular regulation
KW - STAT
KW - Tumor
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U2 - 10.1016/j.molimm.2018.01.014
DO - 10.1016/j.molimm.2018.01.014
M3 - Article
C2 - 29549977
AN - SCOPUS:85046096860
SN - 0161-5890
VL - 110
SP - 24
EP - 39
JO - Molecular Immunology
JF - Molecular Immunology
ER -