TY - JOUR
T1 - Molecular Spectra and Frequency Patterns of Somatic Mutations in Arab Women with Breast Cancer
AU - Al-Shamsi, Humaid O.
AU - Abu-Gheida, Ibrahim
AU - Abdulsamad, Ahmed S.
AU - AlAwadhi, Aydah
AU - Alrawi, Sadir
AU - Musallam, Khaled M.
AU - Arun, Banu
AU - Ibrahim, Nuhad K.
N1 - Publisher Copyright:
© 2021 AlphaMed Press.
PY - 2021/11
Y1 - 2021/11
N2 - Background: The role of somatic mutations in breast cancer prognosis and management continues to be recognized. However, data on the molecular profiles of Arab women are limited. Materials and Methods: This was a cross-sectional study based on medical chart review of all Arab women diagnosed with breast cancer at a single institution between 2010 and 2018 who underwent next-generation sequencing with Ampliseq 46-Gene or 50-Gene. Results: A total of 78 Arab women were identified, with a median age at diagnosis of 52.3 years (range: 37–82 years; 38.5% ≤50 years). The majority of patients had stage III or IV disease (74.4%). Next-generation sequencing revealed the following somatic mutation rates: TP53, 23.1%; ATM, 2.6%; IDH1, 2.6%; IDH2, 3.8%; PTEN, 7.7%; PIK3CA, 15.4%; APC, 7.7%; NPM1, 2.5%; MPL, 1.3%; JAK2, 2.5%; KIT, 7.7%; KRAS, 3.8%; and NRAS, 3.8%. Conclusion: Our study illustrates frequencies of somatic mutations in Arab women with breast cancer and suggests potential variations from estimates reported in the Western population. These data calls for larger epidemiologic studies considering the evolving role of such mutations in prognostication and personalized management.
AB - Background: The role of somatic mutations in breast cancer prognosis and management continues to be recognized. However, data on the molecular profiles of Arab women are limited. Materials and Methods: This was a cross-sectional study based on medical chart review of all Arab women diagnosed with breast cancer at a single institution between 2010 and 2018 who underwent next-generation sequencing with Ampliseq 46-Gene or 50-Gene. Results: A total of 78 Arab women were identified, with a median age at diagnosis of 52.3 years (range: 37–82 years; 38.5% ≤50 years). The majority of patients had stage III or IV disease (74.4%). Next-generation sequencing revealed the following somatic mutation rates: TP53, 23.1%; ATM, 2.6%; IDH1, 2.6%; IDH2, 3.8%; PTEN, 7.7%; PIK3CA, 15.4%; APC, 7.7%; NPM1, 2.5%; MPL, 1.3%; JAK2, 2.5%; KIT, 7.7%; KRAS, 3.8%; and NRAS, 3.8%. Conclusion: Our study illustrates frequencies of somatic mutations in Arab women with breast cancer and suggests potential variations from estimates reported in the Western population. These data calls for larger epidemiologic studies considering the evolving role of such mutations in prognostication and personalized management.
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U2 - 10.1002/onco.13916
DO - 10.1002/onco.13916
M3 - Article
C2 - 34327780
AN - SCOPUS:85112362162
SN - 1083-7159
VL - 26
SP - e2086-e2089
JO - Oncologist
JF - Oncologist
IS - 11
ER -