TY - JOUR
T1 - Molecular targets in cancer drug discovery
T2 - Cell-based profiling
AU - Weinstein, John N.
AU - Buolamwini, John K.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - The phrase 'molecular target-based drug discovery' usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institute's drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig- nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.
AB - The phrase 'molecular target-based drug discovery' usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institute's drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig- nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.
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U2 - 10.2174/1381612003400894
DO - 10.2174/1381612003400894
M3 - Review article
C2 - 10788592
AN - SCOPUS:0034124775
SN - 1381-6128
VL - 6
SP - 473
EP - 483
JO - Current pharmaceutical design
JF - Current pharmaceutical design
IS - 4
ER -