Molecular testing of cytology specimens: overview of assay selection with focus on lung, salivary gland, and thyroid testing

Paul A. VanderLaan; Sinchita Roy-Chowdhuri; Christopher C. Griffith; Vivian L. Weiss; Christine N. Booth

doi:10.1016/j.jasc.2022.08.002

Molecular testing of cytology specimens: overview of assay selection with focus on lung, salivary gland, and thyroid testing

Paul A. VanderLaan, Sinchita Roy-Chowdhuri, Christopher C. Griffith, Vivian L. Weiss, Christine N. Booth

Pathology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Ancillary and molecular testing of cytopathology specimens has emerged as a reliable and useful tool to provide diagnostic information and treatment-related biomarker status for the management of cancer patients. The cytology specimens obtained through minimally invasive means have proven suitable testing substrates for a variety of ancillary tests, including immunohistochemistry, fluorescence in situ hybridization, as well as polymerase chain reaction and next generation sequencing molecular techniques. By focusing specifically on the cytology specimen, this review provides an overview of basic testing considerations and assay selection in addition to updates on the ancillary testing of cytologic tumor specimens from the lung, salivary gland, and thyroid.

Original language	English (US)
Pages (from-to)	403-414
Number of pages	12
Journal	Journal of the American Society of Cytopathology
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/j.jasc.2022.08.002
State	Published - Nov 1 2022

Keywords

Cytology
FISH
Lung
Molecular testing
Next generation sequencing
Salivary gland
Thyroid

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.jasc.2022.08.002

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Molecular testing of cytology specimens: overview of assay selection with focus on lung, salivary gland, and thyroid testing. / VanderLaan, Paul A.; Roy-Chowdhuri, Sinchita; Griffith, Christopher C. et al.
In: Journal of the American Society of Cytopathology, Vol. 11, No. 6, 01.11.2022, p. 403-414.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Ancillary and molecular testing of cytopathology specimens has emerged as a reliable and useful tool to provide diagnostic information and treatment-related biomarker status for the management of cancer patients. The cytology specimens obtained through minimally invasive means have proven suitable testing substrates for a variety of ancillary tests, including immunohistochemistry, fluorescence in situ hybridization, as well as polymerase chain reaction and next generation sequencing molecular techniques. By focusing specifically on the cytology specimen, this review provides an overview of basic testing considerations and assay selection in addition to updates on the ancillary testing of cytologic tumor specimens from the lung, salivary gland, and thyroid.",

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Molecular testing of cytology specimens: overview of assay selection with focus on lung, salivary gland, and thyroid testing

Abstract

Keywords

ASJC Scopus subject areas

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