TY - GEN
T1 - Molecular therapeutic agents for noninvasive photoacoustic image-guided photothermal therapy
AU - Joshi, Pratixa P.
AU - Chen, Yun Sheng
AU - Kim, Seungsoo
AU - Shah, Jignesh
AU - Sokolov, Konstantin
AU - Emelianov, Stanislav
PY - 2009
Y1 - 2009
N2 - Gold nanoparticles are attracting increasing attention in nanomedicine due to their inherently low toxicity and unique optical properties. In particular, gold nanorods have been used in the thermal therapy due to their tunable strong longitudinal plasmon resonance in the near infra-red region and high conversion efficiency from optical to thermal energy. In this study we explore the potential of gold nanorods for photoacoustic image-guided photothermal therapy to treat cancers. We synthesize the gold nanorods and make them biocompatible by replacing the cytotoxic surfactant used in the synthesis (cetyl trimethyl ammonium bromide) with a biocompatible molecule and then demonstrate the targeting to the cancer cells by bioconjugation of the modified nanorods.
AB - Gold nanoparticles are attracting increasing attention in nanomedicine due to their inherently low toxicity and unique optical properties. In particular, gold nanorods have been used in the thermal therapy due to their tunable strong longitudinal plasmon resonance in the near infra-red region and high conversion efficiency from optical to thermal energy. In this study we explore the potential of gold nanorods for photoacoustic image-guided photothermal therapy to treat cancers. We synthesize the gold nanorods and make them biocompatible by replacing the cytotoxic surfactant used in the synthesis (cetyl trimethyl ammonium bromide) with a biocompatible molecule and then demonstrate the targeting to the cancer cells by bioconjugation of the modified nanorods.
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U2 - 10.1109/IEMBS.2009.5334025
DO - 10.1109/IEMBS.2009.5334025
M3 - Conference contribution
C2 - 19964615
AN - SCOPUS:77951020304
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 4106
EP - 4109
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -