TY - JOUR
T1 - Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma
AU - Muñoz, Nina M.
AU - Dupuis, Crystal
AU - Williams, Malea
AU - Dixon, Katherine
AU - McWatters, Amanda
AU - Avritscher, Rony
AU - Bouchard, Richard
AU - Kaseb, Ahmed
AU - Schachtschneider, Kyle M.
AU - Rao, Arvind
AU - Sheth, Rahul A.
N1 - Funding Information:
This work was supported by funds from the Society for Interventional Radiology Foundation, the Radiological Society of North America Research and Education Foundation, and NIH/NIBIB (R21 EB026089-01A1). We acknowledge the use of The University of Texas, MD Anderson Cancer Center’s Flow Cytometry and Cellular Imaging Core Facility (FCCICF), which is partially funded by the NCI Cancer Center Support Grant (P30CA16672). A.R. was supported by institutional startup funds from the University of Michigan, NCI grant R37CA214955 and a Research Scholar Grant from the American Cancer Society (RSG-16-005-01-CCE).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Thermal ablation is a standard therapy for patients with hepatocellular carcinoma (HCC). Contemporary ablation devices are imperfect, as they lack tumor specificity. An ideal ablation modality would generate thermal energy only within tumoral tissue. Furthermore, as hyperthermia is known to influence tumor immunity, such a tumor-specific ablation modality may have the ability to favorably modulate the tumor immune landscape. Here we show a clinically relevant thermal ablation modality that generates tumor-specific hyperthermia, termed molecularly targeted photothermal ablation (MTPA), that is based upon the excellent localization of indocyanine green to HCC. In a syngeneic rat model, we demonstrate the tumor-specific hyperthermia generated by MTPA. We also show through spatial and transcriptomic profiling techniques that MTPA favorably modulates the intratumoral myeloid population towards tumor immunogenicity and diminishes the systemic release of oncogenic cytokines relative to conventional ablation modalities.
AB - Thermal ablation is a standard therapy for patients with hepatocellular carcinoma (HCC). Contemporary ablation devices are imperfect, as they lack tumor specificity. An ideal ablation modality would generate thermal energy only within tumoral tissue. Furthermore, as hyperthermia is known to influence tumor immunity, such a tumor-specific ablation modality may have the ability to favorably modulate the tumor immune landscape. Here we show a clinically relevant thermal ablation modality that generates tumor-specific hyperthermia, termed molecularly targeted photothermal ablation (MTPA), that is based upon the excellent localization of indocyanine green to HCC. In a syngeneic rat model, we demonstrate the tumor-specific hyperthermia generated by MTPA. We also show through spatial and transcriptomic profiling techniques that MTPA favorably modulates the intratumoral myeloid population towards tumor immunogenicity and diminishes the systemic release of oncogenic cytokines relative to conventional ablation modalities.
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U2 - 10.1038/s42003-020-01522-y
DO - 10.1038/s42003-020-01522-y
M3 - Article
C2 - 33335270
AN - SCOPUS:85097683657
SN - 2399-3642
VL - 3
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 783
ER -