Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals

Vijay Sharma; David Piwnica-Worms

doi:10.1007/b101227

Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals

Vijay Sharma, David Piwnica-Worms

Research output: Chapter in Book/Report/Conference proceeding › Chapter

17 Scopus citations

Abstract

Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to successful chemotherapy in cancer patients and there is an expanding requirement to noninvasively interrogate Pgp transport activity in vivo. Both small organic medicinals as well as coordination compounds characterized as transport substrates for MDR1 Pgp are amenable to incorporation of positron emission tomography or single-photon emission computed tomography radionuclides and may enable noninvasive diagnostic imaging of MDR in cancer patients. In particular, several clinically approved [^99mTc] complexes already show promise for the functional evaluation of MDR1 Pgp-mediated transport activity in human tumors in vivo.

Original language	English (US)
Title of host publication	Contrast Agents III
Subtitle of host publication	Radiopharmaceuticals From Diagnostics to Therapeutics
Editors	Werner Krauze
Pages	155-178
Number of pages	24
DOIs	https://doi.org/10.1007/b101227
State	Published - Nov 17 2005
Externally published	Yes

Publication series

Name	Topics in Current Chemistry
Volume	252
ISSN (Print)	0340-1022

Keywords

ATP-binding cassette transporters
Chemotherapeutic agents
Metal complexes
Multidrug resistance
P-glycoprotein
Positron emission tomography
Single-photon emission computed tomography

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1007/b101227

Cite this

Sharma, V., & Piwnica-Worms, D. (2005). Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals. In W. Krauze (Ed.), Contrast Agents III: Radiopharmaceuticals From Diagnostics to Therapeutics (pp. 155-178). (Topics in Current Chemistry; Vol. 252). https://doi.org/10.1007/b101227

Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals. / Sharma, Vijay; Piwnica-Worms, David.
Contrast Agents III: Radiopharmaceuticals From Diagnostics to Therapeutics. ed. / Werner Krauze. 2005. p. 155-178 (Topics in Current Chemistry; Vol. 252).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Sharma, V & Piwnica-Worms, D 2005, Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals. in W Krauze (ed.), Contrast Agents III: Radiopharmaceuticals From Diagnostics to Therapeutics. Topics in Current Chemistry, vol. 252, pp. 155-178. https://doi.org/10.1007/b101227

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Monitoring multidrug resistance P-glycoprotein drug transport activity with single-photon emission computed tomography and positron emission tomography radiopharmaceuticals

Abstract

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Keywords

ASJC Scopus subject areas

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